产品货号：
Z13085
中文名称：
CDK9抗体
英文名称：
Anti-CDK9 Antibody
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CDK9 Antibody |
| 指标别名 | C 2k;CDC2L4;CDK9;Cell division protein kinase 9;CTK1;cyclin dependent kinase 9;PITALRE;TAK |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,IHC,IP,WB |
| 基因名称 | CDK9 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Multiple synthetic peptides corresponding to C-terminal and N-terminal domains of the protein coded by the human gene cdk9 (PITALRE). |
| 计算分子量 | 43kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This product was prepared from monospecific antiserum by delipidation and defibrination.Antiserum will specifically react with a 43kDa cdk9 (PITALRE) protein from human,rat and mouse tissue.No reaction was observed against other related cyclin dependent kinases.Cross-reactivity with cdk9 (PITALRE) from other species may also occur.The murine cDNA is shown to be 98% identical with human.For immunohistochemistry use paraffin embedded tissue. |
| 浓度 | 75mg/mL by Refractometry |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | CDK9 (PITALRE) (also known as cyclin-dependent kinase 9,Serine/threonine-protein kinase PITALRE,C-2K and Cell division cycle 2-like protein kinase 4) is a member of the cyclin-dependent protein kinase (CDK) family.CDK family members are highly similar to the gene products of S.cerevisiae cdc28,and S.pombe cdc2,and known as important cell cycle regulators.CDK9 (PITALRE) interacts with a conserved domain in the TRAF-C region of the tumor necrosis factor signal transducer TRAF2.This kinase also was found to be a component of the multiprotein complex TAK/P-TEFb,which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II.This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K.HIV-1 Tat protein was found to interact with this protein and cyclin T,which suggested a possible involvement of this protein in AIDS.Tat stimulates human HIV-1 viral transcription elongation.This suggests that cyclin T1/cdk9(PITALRE) is one of the HIV-1 required host cellular cofactors generated during T cell activation.Cyclin T1/cdk9(PITALRE) is shown to interact with Tat to restore Tat activation in HeLa nuclear extracts depleted of P-TEFb.The cdk9(PITALRE) activity and cyclin T1 are essential for activation of transcription when tethered to the heterologous Rev response element RNA via the regulator of expression of virion Rev.CDK9 (PITALRE) is a ubiquitously expressed nuclear protein. |
| Uniprot ID | P50750 |
| 基因名全称 | Cyclin-dependent kinase 9 |
| 推荐稀释比 | ELISA:1:10,000 - 1:50,000 IHC:1:200 - 1:1,000 IP:1:100 WB:1:500 - 1:3,000 |
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